A small chapel was established in 1864 by the priests of Milan Mission Seminary in Bonham Road (current site of King’s College) dedicating to St. Anthony as its patron saint.  In 1875, the chapel was then passed on and operated by De La Salle Brothers.  By 1921, the chapel was relocated to the technology workshop within St Louis School in the Third Street, and run by the Maryknoll Fathers.  The technology workshop was taken over by the newly arrived Salesian priests in 1927 with Fr. Galdinus Bardelli appointed as the clergy.  With the increase in population in the western district, the chapel soon became inadequate and the Salesians had made a decision to build a new church.

In post-war 1945, the parish priest Fr. Theodore Wieczorek had personally went to U.S.A. and secured a substantial overseas donation amounting to over $100,000.  With the full support and assistance of the whole congregation, construction went ahead smoothly.  The new church was commissioned on 1.6.1953 and officiated on the feast day of St. Anthony by Bishop Bianchi.

Since its opening in 1953, with the dedication of various priests, the church has been upgraded to provide additional facilities and undergone different stages of renovation to enhance its pasturing work.

In addition, the Our Lady Seat of Wisdom Chapel residing in Ricci Hall of University of Hong Kong has been established as the subsidiary of St Anthony Church.